CLINICAL RESEARCH

Explore Perioban’s cutting-edge clinical studies, where scientific rigor meets a passion for advancing oral health. Delve into ongoing and past trials, uncovering breakthroughs that shape the future of dentistry. Join us in this journey of innovation as we strive for a brighter, healthier tomorrow through Perioban’s commitment to excellence in clinical research.

Implant Trials

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References

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Jepsen, S.; Berglundh, T.; Genco, R.; Aass, A.M.; Demirel, K.; Derks, J.; Figuero, E.; Giovannoli, J.L.; Goldstein, M.; Lambert, F.; et al. Primary prevention of peri-implantitis: Managing peri-implant mucositis. J. Clin. Periodontol. 2015, 42, S152–S157.

Schwarz, F.; Derks, J.; Monje, A.; Wang, H.L. Peri-implantitis. J. Clin. Periodontol. 2018, 45, S246–S266.

Liaw, K.; Delfini, R.H.; Abrahams, J.J. Dental Implant Complications. Semin. Ultrasound CT MR 2015, 36, 427–433.

Lindhe, J.; Meyle, J.; Group DoEWoP. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J. Clin. Periodontol. 2008, 35, 282–285.

Berglundh, T.; Armitage, G.; Araujo, M.G.; Avila-Ortiz, G.; Blanco, J.; Camargo, P.M.; Chen, S.; Cochran, D.; Derks, J.; Figuero, E.; et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Clin. Periodontol. 2018, 45, S286–S291.

Berglundh, T.; Lindhe, J.; Marinello, C.; Ericsson, I.; Liljenberg, B. Soft tissue reaction to de novo plaque formation on implants and teeth. An experimental study in the dog. Clin. Oral Implant. Res. 1992, 3, 1–8. Appl. Sci. 2022, 12, 2800

Salvi, G.E.; Aglietta, M.; Eick, S.; Sculean, A.; Lang, N.P.; Ramseier, C.A. Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans. Clin. Oral Implant. Res. 2012, 23, 182–190.

Schwarz, F.; Mihatovic, I.; Golubovic, V.; Eick, S.; Iglhaut, T.; Becker, J. Experimental peri implant mucositis at different implant surfaces. J. Clin. Periodontol. 2014, 41, 513–520.

Roccuzzo, M.; Bonino, F.; Aglietta, M.; Dalmasso, P. Ten-year results of a three arms prospective cohort study on implants in periodontally compromised patients. Part 2: Clinical results. Clin. Oral Implants Res. 2012, 23, 389–395.

Lindquist, L.W.; Carlsson, G.E.; Jemt, T. A prospective 15-year follow-up study of mandibular fixed prostheses supported by osseointegrated implants. Clinical results and marginal bone loss. Clin. Oral Implants Res. 1996, 7, 329–336.

Ferreira, S.D.; Silva, G.L.M.; Cortelli, J.R.; Costa, J.E.; Costa, F.O. Prevalence and risk variables for peri-implant disease in Brazilian subjects. J. Clin. Periodontol. 2006, 33, 929–935.

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Gobbato, L.; Avila-Ortiz, G.; Sohrabi, K.; Wang, C.W.; Karimbux, N. The effect of keratinized mucosa width on peri-implant health: A systematic review. Int. J. Oral Maxillofac. Implants. 2013, 28, 1536–1545.

Laine, M.L.; Leonhardt, Å.; Roos-Jansåker, A.M.; Peña, A.S.; Van Winkelhoff, A.J.; Winkel, E.G.; Renvert, S. IL-1RN gene polymorphism is associated with peri-implantitis. Clin. Oral Implant. Res. 2006, 17, 380–385.

Korsch, M.; Obst, U.; Walther, W. Cement-associated peri-implantitis: A retrospective clinical observational study of fixed implant-supported restorations using a methacrylate cement. Clin. Oral Implant. Res. 2014, 25, 797–802.

Renvert, S.; Aghazadeh, A.; Hallstrom, H.; Persson, G.R. Factors related to peri-implantitis-A retrospective study. Clin. Oral Implant. Res. 2014, 25, 522–529.

Lang, N.P.; Berglundh, T.; Working Group 4 of Seventh European Workshop on Periodontology. Periimplant diseases: Where are we now?—Consensus of the Seventh European Workshop on Periodontology. J. Clin. Periodontol. 2011, 38, 178–181.

Kozlovsky, A.; Tal, H.; Laufer, B.-Z.; Leshem, R.; Rohrer, M.D.; Weinreb, M.; Artzi, Z. Impact of implant overloading on the peri-implant bone in inflamed and non-inflamed peri-implant mucosa. Clin. Oral Implant. Res. 2007, 18, 601–610.

Fretwurst, T.; Buzanich, G.; Nahles, S.; Woelber, J.P.; Riesemeier, H.; Nelson, K. Metal elements in tissue with dental periimplantitis: A pilot study. Clin. Oral Implant. Res. 2016, 27, 1178–1186.

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Mombelli, A. Microbial colonization of the periodontal pocket and its significance for periodontal therapy. Periodontology 2000 2018, 76, 85–96.

Feres, M. Antibiotics in the treatment of periodontal diseases: Microbiological basis and clinical applications. Ann. R Australas. Coll. Dent. Surg. 2008, 19, 37–44.

Butera, A.; Gallo, S.; Pascadopoli, M.; Luraghi, G.; Scribante, A. Ozonized Water Administration in Peri-Implant Mucositis Sites: A Randomized Clinical Trial. Appl. Sci. 2021, 11, 7812.

Meimandi, M.; Talebi Ardakani, M.R.; Esmaeil Nejad, A.; Yousefnejad, P.; Saebi, K.; Tayeed, M.H. The Effect of Photodynamic Therapy in the Treatment of Chronic Periodontitis: A Review of Literature. J. Lasers Med. Sci. 2017, 8, S7–S11.

Invernici, M.M.; Salvador, S.L.; Silva, P.; Soares, M.; Casarin, R.; Palioto, D.B.; Souza, S.; Taba, M., Jr.; Novaes, A.B., Jr.; Furlaneto, F.; et al. Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial.

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Piepho, H.P. An Algorithm for a Letter-Based Representation of All-Pairwise Comparisons. J. Comput. Graph. Stat. 2004, 13, 456–466.

Appl. Sci. 2022, 12, 2800

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Ong, C.T.T.; Ivanoski, S.; Needleman, I.G.; Retzepi, M.; Moles, D.R.; Tonetti, M.S.; Donos, N. Systematic review of implant outcomes in treated periodontitis subjects. J. Clin. Periodontol. 2008, 35, 438–462.

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Lang, N.P.; Berglundh, T.; Heitz-Mayfield, L.J.; Pjetursson, B.E.; Salvi, G.E.; Sanz, M. Consensus statements and recommended clinical procedures regarding implant survival and complications. Int. J. Oral Maxillofac. Implant. 2004, 19, 150–154.

Ikram,S.; Hassan, N.; Raffat, M.A.; Mirza, S.; Akram, Z. Systematic review and meta-analysis of double- blind, placebo-controlled, randomized clinical trials using probiotics in chronic periodontitis. J. Investig. Clin. Dent. 2018, 9, e12338. [CrossRef] [PubMed]

Vivekananda, M.R.; Vandana, K.L.; Bhat, K.G. Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: A preliminary randomized clinical trial. J. Oral Microbiol. 2010, 2, 5344.

Cereda, E.; Caraccia, M.; Caccialanza, R. Probiotics and mucositis. Curr. Opin. Clin. Nutr. Metab. Care 2018, 21, 399–404.

Zhao, R.; Hu, H.; Wang, Y.; Lai, W.; Jian, F. Efficacy of Probiotics as Adjunctive Therapy to Nonsurgical Treatment of Peri-Implant Mucositis: A Systematic Review and Meta-Analysis. Front. Pharmacol. 2021, 11, 541752.

Varoni, E.; Tarce, M.; Lodi, G.; Carrassi, A. Chlorhexidine (CHX) in dentistry: State of the art. Minerva Stomatol. 2012, 61, 399–419.

Haydari, M.; Bardakci, A.G.; Koldsland, O.C.; Aass, A.M.; Sandvik, L.; Preus, H.R. Comparing the effect of 0.06%-, 0.12% and 0.2% Chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: A parallel group, double masked randomized clinical trial. BMC Oral Health 2017, 17, 118.

Ishikawa, K.H.; Bueno, M.R.; Kawamoto, D.; Simionato, M.R.L.; Mayer, M.P.A. Lactobacilli postbiotics reduce biofilm formation and alter transcription of virulence genes of Aggregatibacter actinomycetemcomitans. Mol. Oral Microbiol. 2021, 36, 92–102.

Vale, G.C.; Mayer, M.P.A. Effect of probiotic Lactobacillus rhamnosus by-products on gingival epithelial cells challenged with Prphyromonas gingivalis. Arch. Oral Biol. 2021, 128, 105174.

Butera, A.; Gallo, S.; Pascadopoli, M.; Taccardi, D.; Scribante, A. Home Oral Care of Periodontal Patients Using Antimicrobial Gel with Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf Juice Powder vs. Conventional Chlorhexidine Gel: A Split-Mouth Randomized Clinical Trial. Antibiotics 2022, 11, 118.

Lee, J.; Park, S.; Oh, N.; Park, J.; Kwon, M.; Seo, J.; Roh, S. Oral intake of Lactobacillus plantarum L-14 extract alleviates TLR2 and AMPK-mediated obesity- associated disorders in hight-fat-diet-induced obese C57BL/6J mice. Cell Prolif. 2021, 54, e13039

Jung, R.E.; Pjetursson, B.E.; Glauser, R.; Zembic, A.; Zwahlen, M.; Lang, N.P. A systematic review of the 5-year survival and complication rates of implant-supported single crowns. Clin. Oral Implants Res. 2008, 19, 119–130.

Jepsen, S.; Berglundh, T.; Genco, R.; Aass, A.M.; Demirel, K.; Derks, J.; Figuero, E.; Giovannoli, J.L.; Goldstein, M.; Lambert, F.; et al.

Primary prevention of peri-implantitis: Managing peri-implant mucositis. J. Clin. Periodontol. 2015, 42, S152– S157.

Schwarz, F.; Derks, J.; Monje, A.; Wang, H.L. Peri-implantitis. J. Clin. Periodontol. 2018, 45, S246–S266.

Liaw, K.; Delfini, R.H.; Abrahams, J.J. Dental Implant Complications. Semin. Ultrasound CT MR 2015, 36, 427– 433.

Lindhe, J.; Meyle, J.; Group DoEWoP. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J. Clin. Periodontol. 2008, 35, 282–285.

Berglundh, T.; Armitage, G.; Araujo, M.G.; Avila-Ortiz, G.; Blanco, J.; Camargo, P.M.; Chen, S.; Cochran, D.; Derks, J.; Figuero, E.; et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Clin. Periodontol. 2018, 45, S286–S291.

Berglundh, T.; Lindhe, J.; Marinello, C.; Ericsson, I.; Liljenberg, B. Soft tissue reaction to de novo plaque formation on implants and teeth. An experimental study in the dog. Clin. Oral Implant. Res. 1992, 3, 1–8. Appl. Sci. 2022, 12, 2800

Salvi, G.E.; Aglietta, M.; Eick, S.; Sculean, A.; Lang, N.P.; Ramseier, C.A. Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans. Clin. Oral Implant. Res. 2012, 23, 182–190.

Schwarz, F.; Mihatovic, I.; Golubovic, V.; Eick, S.; Iglhaut, T.; Becker, J. Experimental peri-implant mucositis at different implant surfaces. J. Clin. Periodontol. 2014, 41, 513–520.

Roccuzzo, M.; Bonino, F.; Aglietta, M.; Dalmasso, P. Ten-year results of a three arms prospective cohort study on implants in periodontally compromised patients. Part 2: Clinical results. Clin. Oral Implants Res. 2012, 23, 389–395.

Lindquist, L.W.; Carlsson, G.E.; Jemt, T. A prospective 15-year follow-up study of mandibular fixed prostheses supported by osseointegrated implants. Clinical results and marginal bone loss. Clin. Oral Implants Res. 1996, 7, 329–336.

Ferreira, S.D.; Silva, G.L.M.; Cortelli, J.R.; Costa, J.E.; Costa, F.O. Prevalence and risk variables for peri-implant disease in Brazilian subjects. J. Clin. Periodontol. 2006, 33, 929–935.

Costa, F.O.; Takenaka-Martinez, S.; Cota, L.O.M.; Ferreira, S.D.; Silva, G.L.M.; Costa, J.E. Peri-implant disease in subjects with and without preventive maintenance: A 5-year follow-up. J. Clin. Periodontol. 2012, 39, 173–181.

Gobbato, L.; Avila-Ortiz, G.; Sohrabi, K.; Wang, C.W.; Karimbux, N. The effect of keratinized mucosa width on peri-implant health: A systematic review. Int. J. Oral Maxillofac. Implants. 2013, 28, 1536–1545.

Laine, M.L.; Leonhardt, Å.; Roos-Jansåker, A.M.; Peña, A.S.; Van Winkelhoff, A.J.; Winkel, E.G.; Renvert, S. IL 1RN gene polymorphism is associated with peri-implantitis. Clin. Oral Implant. Res. 2006, 17, 380–385.

Korsch, M.; Obst, U.; Walther, W. Cement-associated peri-implantitis: A retrospective clinical observational study of fixed implant-supported restorations using a methacrylate cement. Clin. Oral Implant. Res. 2014, 25, 797–802.

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